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Entwicklung neuer übergangsmetallkatalysierter Reaktionen zum gezielten Aufbau von neuen C-C-, C-N-, C-S- und C-O-Bindungen, asymmetrische Synthese, Entwicklung einer parallelen, automatisierbaren, modularen Kohlenhydratsynthese zum Aufbau strukturell definierter Substanzbibliotheken, Naturstoffsynthese.

Development of transition metal catalyzed reaction for the selective generation of new C-C-, C-N-, C-S- and C-O-bonds; asymmetric synthesis; development of a parallel, automatable, modular carbohydrate synthesis for the generation of a structural defined substance library; natural product synthesis.

Christine's paper on the "General Stereodivergent Enantioselective Total Synthetic Approach toward Macrosphelides A–G and M" is online available

Posted by Bernd Plietker (plietker) on Aug 04 2015
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Christine was able to develop a straightforward enantioselective total synthesis algorithm for the preparation of 8 out of 13 macrosphelides within 9–11 steps starting from tert-butyl sorbate. The use of a cyclic sulfate as both protecting and reactivity directing group is the key element within this algorithm. A high-pressure transesterification allows for the selective ring-enlargement of the 15-membered macrosphelides into the 16-membered counterparts.


Last changed: Aug 04 2015 at 14:11